Señor Sto. Niño Hospital, Inc. started as a small diagnostic and lying-in medical clinic lovated along Quezon Avenue Camiling, tarlac on December 08, 1988 and was formerly known as Nuestro Señor Sto. Niño Medical Diagnostic Clinic.

The success of Señor Sto. Niño as a diagnostic and lying-in clinic inspired Dr. Ronaldo M. Toledo, its founder, to expand its medical services on larger scale. He saw the need to provide quality and affordable healthcare services to his valued patients through highly qualified medical professionals and modern medical equipment.